Abcam, ab238577, Anti-PIGN antibody

Size: 100µL
Rabbit Polyclonal PIGN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PIGN aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PIGN aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O95427

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PIGN also known as Phosphatidylinositol Glycan Anchor Biosynthesis Class N is a protein involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis. This protein facilitates the transfer of ethanolamine phosphate to the third mannose in the GPI anchor precursor. The molecular mass of PIGN is approximately 52 kDa. Expression of PIGN is widespread across various tissues including liver pancreas and kidney.
Biological function summary
PIGN plays an important role in anchoring proteins to the cell membrane by forming part of the GPI transamidase complex. This complex which includes other proteins such as PIGK PIGS and GPAA1 is essential for the attachment of GPI anchors to proteins. PIGN ensures correct positioning and functionality of proteins on the cell surface affecting cell-cell communication and signaling.
Pathways
PIGN participates in the GPI-anchor biosynthesis pathway. This pathway is important for the surface display of many proteins influencing processes like immune response and signal transduction. PIGN's role is tied to the trafficking and localization of GPI-anchored proteins. It also interacts with proteins like PIGA in the same biosynthetic pathway maintaining the integrity and function of cell membranes.
PIGN mutations have links to multiple congenital abnormalities including Mabry syndrome characterized by symptoms like intellectual disability and hyperphosphatasia. Furthermore studies associate PIGN with cancer due to its role in cell signaling and proliferation. Alterations in the expression or function of PIGN could affect related proteins like PIGV contributing to these conditions.