Abcam, ab238820, Anti-Claudin 15 antibody

Size: 100µL
Rabbit Polyclonal Claudin 15 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Claudin-15 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Claudin-15 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.P56746

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Claudin 15 also called CLDN15 is a member of the claudin family which are integral membrane proteins and a component of tight junctions. These proteins contribute to the establishment and maintenance of cell polarity and paracellular barrier functions. Claudin 15 has a molecular mass of approximately 23 kDa. The protein is prominently expressed in the epithelial cells of organs such as the intestines. Its role involves forming tight junction strands which act as barriers and limit the passage of ions and small molecules between cells.
Biological function summary
Claudin 15 regulates ion selectivity and paracellular permeability. As part of tight junctions claudin 15 helps manage the movement of ions including sodium and chloride across epithelial barriers. The protein is part of a complex with other claudin family members such as claudin 1 and claudin 2 which collectively regulate barrier functions. This ensures proper nutrient absorption and gut homeostasis.
Pathways
Claudin 15 participates in maintaining the integrity of tight junction protein networks that influence epithelial tissue structure. It plays a role in the Wnt signaling pathway which regulates cellular proliferation and differentiation. Claudin 15 interacts with other proteins in this network including E-cadherin and beta-catenin to modulate cell adhesion and signaling processes necessary for tissue development and repair.
Claudin 15 has significant implications in intestinal barrier function and related pathologies. Dysfunction or abnormal expression of claudin 15 associates with intestinal disorders such as inflammatory bowel disease (IBD). Aberrant claudin 15 expression may also influence interactions with other proteins such as Zonula occludens-1 which impacts the integrity of intestinal epithelial barriers and leads to increased permeability and inflammation in these conditions.