Abcam, ab238855, Anti-TTDA antibody

Size: 100µg / 100µL
Rabbit Polyclonal TTDA antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GTF2H5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GTF2H5.Q6ZYL4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTDA also known as GTF2H5 or TFB5 is a small protein with a mass of approximately 8.4 kDa. It functions as a part of the transcription factor IIH (TFIIH) complex which is essential in DNA repair and transcription. TTDA is expressed in various tissues throughout the body with notable expression in actively dividing cells. Mechanically TTDA interacts with other components within the TFIIH complex to stabilize its structure and support its activities during transcription and nucleotide excision repair (NER).
Biological function summary
This protein plays a role in maintaining genomic integrity by ensuring effective DNA repair. Acting as part of the TFIIH complex TTDA facilitates the recognition and excision of damaged DNA segments through the NER process. It also contributes to the transcription initiation process by unwinding DNA and permitting the RNA polymerase to access the DNA template. These roles are critical for cellular processes like replication and transcription which require accurate and clean DNA templates.
Pathways
TTDA is important in the nucleotide excision repair and transcription initiation pathways. Within the NER pathway TTDA works alongside other TFIIH complex members such as XPB and XPD which helicases that help unwind DNA. In transcription initiation TTDA is related to the functioning of RNA polymerase II ensuring successful transcription starts. The interconnection of TTDA with these processes highlights its contribution to cellular health and replication fidelity.
Mutations or dysfunctions regarding TTDA can lead to conditions such as trichothiodystrophy and xeroderma pigmentosum. These disorders arise from impaired DNA repair mechanisms due to faulty TFIIH complex activities leading to increased sensitivity to UV light and abnormal skin and hair development. TTDA's interaction with other NER proteins like XPD suggests its involvement in maintaining a robust response to DNA damage and its malfunction can contribute to the onset of these genetic disorders.