Abcam, ab238939, Anti-ACOX1/AOX antibody [EPR19038] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ACOX1/AOX antibody. Carrier free. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19038,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab238939 is the carrier-free version of
ab184032
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACOX1 also known as AOX or AOX animal plays an important role in peroxisomal beta-oxidation of fatty acids. This enzyme catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. ACOX1 with a mass of approximately 73 kDa is primarily expressed in liver and kidney tissues where it contributes to lipid metabolism. The functionality of this protein is essential for maintaining the balance of fatty acids within the peroxisome which is an important organelle in cellular lipid homeostasis.
Biological function summary
ACOX1 functions as part of the fatty acid oxidation process by ensuring the efficient breakdown of very long-chain fatty acids. This enzyme operates in conjunction with other proteins involved in the beta-oxidation enzyme complex. The activity of ACOX1 is significant for energy production metabolizing long-chain fatty acids which accumulate under normal physiological conditions. Proper function of this enzyme ensures that excessive accumulation of these fatty acids does not occur which can otherwise lead to cellular stress or dysfunction.
Pathways
ACOX1 fits into lipid metabolism pathways specifically the peroxisomal beta-oxidation pathway. This pathway is critical for the breakdown of long and very long-chain fatty acids. ACOX1 functions together with other peroxisomal enzymes such as peroxisomal acyl-coenzyme A oxidase 2 (ACOX2) to complete this metabolic process. Both these enzymes work in tandem to manage fatty acid levels within the peroxisomal pathway ensuring smooth cellular energy homeostasis and overall metabolic function.
Mutations or deficiencies in ACOX1 relate closely to conditions like adrenoleukodystrophy and Zellweger syndrome. These disorders arise from impaired peroxisomal function leading to the accumulation of very long-chain fatty acids that are typically processed by ACOX1. Such accumulations can exacerbate neurological and hepatic disorders. Additionally a dysfunctional interaction between ACOX1 and peroxisomal protein peroxin 1 (PEX1) can result in compromised peroxisome function further contributing to the pathology of these disorders.