Abcam, ab238992, Anti-CREB3 antibody [EPR14215(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CREB3 antibody. Carrier free. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14215(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab238992 is the carrier-free version of
ab180119
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CREB3 also known as Cyclic AMP-responsive element-binding protein 3 is a transcription factor. It belongs to the bZIP family and features a basic-leucine zipper domain that facilitates DNA binding. This protein weighs approximately 55 kDa. CREB3 is primarily expressed in the liver and the secretory tissues where it helps in regulating various genes.
Biological function summary
CREB3 activates transcription by binding to cyclic AMP-responsive elements (CRE) in the promoters of target genes. It forms part of a wider regulatory network and can interact with other transcription factors to modulate gene expression. This protein is involved in the unfolded protein response which is essential for maintaining cellular homeostasis particularly under stress conditions.
Pathways
CREB3 plays an important role in the endoplasmic reticulum stress response pathway. It helps in the regulation of genes involved in protein folding and secretion. CREB3 also interacts with other proteins such as ATF6 which operates in similar pathways to coordinate cell survival and adaptation mechanisms under stress.
Altered CREB3 function has been linked to metabolic disorders including liver diseases such as non-alcoholic fatty liver disease. Additionally its dysregulation may be implicated in neurodegenerative disorders potentially through interaction with proteins like GRP78 which is also involved in the unfolded protein response. These associations highlight CREB3's importance in managing stress responses and maintaining proper cellular function.