Abcam, ab239147, Anti-Transmembrane protein 93/EMC6 antibody

Size: 100µL
Rabbit Polyclonal Transmembrane protein 93/EMC6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human EMC6 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EMC6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9BV81

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Transmembrane protein 93 also known as EMC6 functions as a membrane protein in intracellular transport and protein folding. EMC6 is part of the endoplasmic reticulum membrane protein complex (EMC) and has a molecular mass of approximately 26 kDa. It expresses widely in various tissues including brain heart liver and kidney suggesting a broad role in cellular processes.
Biological function summary
This protein interacts with other components in the endoplasmic reticulum and is essential for proper folding and insertion of proteins into the ER membrane. EMC6 functions as part of a larger scaffolding complex that supports ER-associated degradation (ERAD) which is necessary for maintaining protein homeostasis. This complex plays an important role in quality control by removing misfolded proteins and EMC6 specifically contributes to the stabilization and function of this complex.
Pathways
EMC6 has important roles in the ER stress response and autophagy pathways. The protein interacts with autophagy-related proteins including Beclin 1 facilitating the cellular recycling process. Through the ER stress response EMC6 participates in maintaining cellular health by assisting in protein refolding and degradation pathways linking its function to the action of other ER stress-related proteins like IRE1 and PERK.
EMC6 associates with conditions like neurodegenerative diseases and certain cancers. The protein's involvement in autophagy links it to Alzheimer's disease where accumulation of defective proteins occurs. Additionally disruptions in EMC6 function may contribute to oncogenesis by impairing protein quality control with its role in ERAD connecting it to the growth of cancerous cells. Altered expression or function of EMC6 can correlate with disease pathogenesis making it a point of interest for therapeutic research.