Abcam, ab239749, PD-L1 Antibody Panel (28-8, 73-10, SP142, CAL10)

Size: 1Kit
PD-L1 Antibody Panel (28-8, 73-10, SP142, CAL10) (ab239749) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
Product details:
PD-L1 Antibody Panel ab239749 is a panel of 4 recombinant rabbit monoclonal antibodies against human PD-L1. They are provided in small sizes to allow you to easily evaluate which is the best PD-L1 antibody for your human PD-L1 research assay needs. For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.Panel contains: - Rabbit monoclonal [73-10] to PD-L1 (10 µL)
ab228415
- Rabbit monoclonal [28-8] to PD-L1 (10 µL)
ab205921
- Rabbit monoclonal [SP142] to PD-L1 (25 µL)
ab228462
- Rabbit monoclonal [CAL10] to PD-L1 (10 µL) ab237726See our to help you find the optimal recombinant monoclonal PD-L1 antibody clone for your research.
All of the antibodies are ideal for use with immunohistochemistry with paraffin-embedded / formalin-fixed sections (as well as with other techniques).
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PD-L1 also known as Programmed Death-Ligand 1 or CD274 is a protein involved in immune modulation. Mechanically PD-L1 interacts with its receptors particularly PD-1 to regulate cellular immune responses. This transmembrane protein has a calculated molecular weight of approximately 33 kDa. PD-L1 is expressed on various cell types including tumor cells and immune cells such as dendritic cells macrophages and B cells. Its expression is often upregulated in response to inflammatory cytokines.
Biological function summary
PD-L1 plays a central role in immune evasion mechanisms utilized by tumors. It is not part of a larger protein complex but directly interacts with PD-1 and CD80. When PD-L1 binds to PD-1 it sends inhibitory signals leading to decreased T cell activation and proliferation allowing cancer cells to avoid immune destruction. PD-L1 expression provides a mechanism for tumors to suppress immune surveillance facilitating tumor progression.
Pathways
PD-L1 is integral to the immune checkpoint pathway which is an important regulator of immune response. The interaction between PD-L1 and PD-1 provides a mechanism for immune tolerance which is part of the broader adaptive immune system pathway. PD-L1 is related to other immune checkpoint proteins such as CTLA-4 in its function to limit autoreactivity and promote immune homeostasis.
PD-L1 is most associated with cancer particularly in tumors such as melanoma and non-small cell lung cancer. PD-L1 expression on tumor cells often correlates with poor prognosis. PD-L1 directly interacts with PD-1 in these cancers a target for immunotherapies such as checkpoint inhibitors which aim to block this interaction and restore immune activity against tumors. PD-L1 involvement extends to autoimmune disorders where altered expression can impact tolerance and lead to immune-related tissue damage.