Abcam, ab240108, Anti-delta Sarcoglycan antibody [EPR8706] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal delta Sarcoglycan antibody. Carrier free. Suitable for mIHC, IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8706,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IP, IHC-P, mIHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab240108 is the carrier-free version of
ab137101
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Delta Sarcoglycan also known as SGCD is a protein component of the sarcoglycan complex. It has an approximate mass of 35 kDa. Delta Sarcoglycan localizes predominantly in skeletal and cardiac muscle tissues. This protein forms part of a set of transmembrane glycoproteins which are integral to the muscle cell membrane. It plays an important role in maintaining the structural integrity of muscle cells by linking the sarcolemma to the extracellular matrix.
Biological function summary
Delta Sarcoglycan associates with other sarcoglycan proteins to form the sarcoglycan complex. This complex is an essential part of the dystrophin-associated glycoprotein complex (DAGC) which connects the cytoskeleton of a muscle fiber to the extracellular matrix. The proper function of this complex is essential for muscle stability during contraction and relaxation preventing damage to the muscle fibers. It interacts with dystrophin an essential adapter protein which anchors the sarcolemma to the cytoskeleton.
Pathways
Delta Sarcoglycan plays an integral role in maintaining the integrity of the dystrophin-glycoprotein complex pathway which is vital for muscle function. It also involves the adhesion and signaling pathways that influence muscle cell adhesion and communication. It shows a relationship with dystrophin where mutations in genes coding for any component including delta Sarcoglycan disrupt these pathways and affect muscle tissue integrity.
Delta Sarcoglycan mutations are primarily linked to limb-girdle muscular dystrophy type 2F (LGMD2F) and specific types of cardiomyopathy. These conditions manifest through progressive muscle weakness and deterioration emphasizing the protein’s significance in muscle health. Mutations in the dystrophin protein can exacerbate these diseases further illustrating the important synergy between dystrophin and sarcoglycan complex including delta Sarcoglycan in maintaining muscle integrity.