Abcam, ab241361, Anti-RIOK3 antibody

Size: 100µL
Rabbit Polyclonal RIOK3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RIOK3 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RIOK3 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O14730

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241361 was affinity purified using an epitope specific to RIOK3 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIOK3 also known as RIO kinase 3 or SUDD is a serine/threonine kinase with a molecular mass of approximately 65 kDa. This protein acts as an atypical kinase within the RIO kinase family and localizes to the cytoplasm. RIOK3 shows expression in various tissues with higher levels notably in the immune system including the spleen and thymus. Unlike typical kinases RIOK3 contains a unique winged-helix domain that contributes to its diverse functions in cellular processes.
Biological function summary
RIOK3 participates in immune response regulation and cellular signal transduction. It does not form part of any known large protein complex but interacts with several other proteins through transient associations. By modulating pathways involved in immune processes RIOK3 affects the activation state of various immune cells. It is involved in the regulation of interferon production where it works closely with other signaling proteins to modulate responses to viral infections.
Pathways
RIOK3 serves a role in the innate immune response and RNA processing pathways. It influences the retinoic acid-inducible gene I (RIG-I) pathway where it interacts with proteins such as RIG-I and MAVS to mediate antiviral responses. Additionally RIOK3 plays a modulatory role in mRNA processing connecting with proteins involved in RNA maturation and internationalization which suggests its involvement in maintaining proper RNA homeostasis under stress conditions.
RIOK3 has associations with autoimmune conditions and viral infections highlighting its role in immune regulation. Aberrant functioning of RIOK3 can relate to systemic lupus erythematosus (SLE) where it influences the overproduction of interferons exacerbating the disease phenotype. Furthermore RIOK3 modulates responses to hepatitis C virus infections interacting with proteins such as RIG-I to control viral replication and immune evasion. Understanding RIOK3's functions can lead to insights into therapeutic interventions for these conditions.