Abcam, ab241472, Anti-SEC10 antibody

Size: 100µg
Rabbit Polyclonal SEC10 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EXOC5 aa 650 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EXOC5 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O00471

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241472 was affinity purified using an epitope specific to SEC10 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEC10 also known as Exocyst complex component 5 weighs approximately 89 kDa. It plays a pivotal role in exocytosis by forming part of the exocyst complex. You can find SEC10 expressed in a broad range of tissues including epithelial cells and neuronal cells. In these cells it is integral to vesicle trafficking where it aids in tethering secretory vesicles to specific sites on the plasma membrane.
Biological function summary
SEC10 is an integral component of the exocyst complex which plays an important role in the final stages of vesicle fusion with the plasma membrane. This complex consists of proteins like Sec3 Sec5 Sec6 Sec8 Sec10 Sec15 Exo70 and Exo84. SEC10's specific contribution to the exocyst complex is in facilitating the spatial regulation of vesicle docking impacting processes like cell migration and growth regulation.
Pathways
SEC10 participates in important biological pathways such as the vesicle-mediated transport and endocytosis pathways. Through these pathways it interacts with proteins like Rab GTPases and SNAREs assisting in the proper fusion of vesicles with the destination membrane. SEC10's ability to correlate vesicle movement with membrane sites helps maintain cellular homeostasis and signal transduction.
SEC10 reflects a connection with developmental and neurological disorders. Abnormal SEC10 function can disrupt vesicle trafficking impacting proteins like SNAP-25 leading to developmental delays or neurodegenerative diseases. Anomalies in exocyst-mediated pathways can cause improper cell communication influencing disease progression. Understanding SEC10's function and pathways can aid in developing better therapeutic strategies for related conditions.