Abcam, ab241487, Anti-NAT13 antibody

Size: 100µL
Rabbit Polyclonal NAT13 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NAA50 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NAA50 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9GZZ1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to NAT13 immobilized on solid support, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The N-acetyltransferase 13 (NAT13) also known as GCN5-related N-acetyltransferase-like 3 is a protein involved in acetylation processes. It has a molecular mass of about 25 kDa. NAT13 is known for its specific role in the acetylation of polyamines important for cellular metabolism. This protein is expressed in various tissues with significant presence in the liver and kidney. The widespread expression suggests its importance in maintaining normal cellular function.
Biological function summary
NAT13 exerts its effects on cellular growth modulation and proliferation. NAT13 functions as a part of the enzyme complexes that regulate the acetylation process modifying substrates in the cell. This modification impacts protein function stability and interaction with other cellular components. NAT13's enzymatic activity influences cell cycle regulation and is critical for normal cell growth and division.
Pathways
NAT13 influences polyamine biosynthesis and metabolism which are necessary for cell replication and growth. One of the significant pathways involving NAT13 is the spermidine and spermine biosynthesis pathway which interacts with the polyamine oxidase enzyme. These interactions help to balance cellular growth signals and maintain cellular homeostasis. Another associated pathway is histone acetylation impacting gene expression regulation and being correlated with the GCN5 protein.
NAT13 has connections to colorectal cancer and hepatocellular carcinoma due to its role in cell cycle regulation and proliferation. Aberrant activity of NAT13 can disrupt normal acetylation patterns leading to uncontrolled cell growth associated with tumorigenesis. Additionally NAT13's dysregulation links with proteins such as c-Myc known for their part in oncogenic processes. Understanding NAT13's activity offers insights into the molecular mechanisms behind these cancers and potential therapeutic targets.