Abcam, ab241578, Anti-UTP18 antibody

Size: 100µL
Rabbit Polyclonal UTP18 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UTP18 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UTP18 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9Y5J1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241578 was affinity purified using an epitope specific to UTP18 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UTP18 also known as U3 small nucleolar RNA-associated protein 18 plays a mechanical role in the assembly and maturation of small subunit (SSU) ribosomal RNA. UTP18 with an approximate mass of 35 kDa functions as part of the UTP-B module of the SSU processome. It is expressed primarily in the nucleolus of eukaryotic cells where it facilitates rRNA synthesis and processing an essential step in ribosome biogenesis.
Biological function summary
UTP18 contributes to the early processing stages of the 18S rRNA and is integral to the formation of the SSU processome. This protein is part of a larger complex known as the small subunit (SSU) processome which contains several U3 small nucleolar RNAs and numerous protein subunits. Its activity supports the assembly of ribosomal subunits an essential function for cellular protein synthesis and growth.
Pathways
UTP18 participates in ribosome biogenesis and nucleotide metabolism in eukaryotic cells. It associates with various proteins such as UTP14 and others within the SSU processome to ensure proper rRNA processing. UTP18 action affects the ribosome biogenesis pathway directly impacting translation and cellular metabolism.
Mutations or dysregulation of UTP18 have links to ribosomopathies which involve impaired ribosome function. Disorders such as Diamond-Blackfan anemia characterized by defective erythropoiesis may involve issues with UTP18 function. Its interactions with other SSU processome components suggest that any disruptions in this protein complex might contribute to disease pathology affecting ribosomal assembly and cellular protein synthesis.