Abcam, ab242088, Anti-Erasin antibody

Size: 100µL
Rabbit Polyclonal Erasin antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UBXN4 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UBXN4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92575

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to Erasin immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Erasin also known as X15H8 protein is a cellular protein with a mass of approximately 54 kDa. It functions as a molecular chaperone by helping in the folding and assembly of nascent polypeptides into functional proteins. Erasin is expressed mostly in liver and kidney tissues but can also be found in smaller amounts in other organs. This expression pattern supports its involvement in maintaining protein homeostasis and cellular proteostasis mechanisms in metabolically active tissues.
Biological function summary
The roles of Erasin extend beyond its chaperone activities. It is a component of a larger proteostasis network interacting with other cellular machineries to regulate degradation processes. Erasin helps in stabilizing misfolded proteins and prevents aggregation which could be harmful to the cell. Its presence in the endoplasmic reticulum signifies its function in protein quality control and stress response especially under conditions that challenge cellular homeostasis.
Pathways
Erasin actively participates in the unfolded protein response (UPR) and ER-associated degradation (ERAD) pathways. These pathways are important for eliminating defective proteins and maintaining cellular equilibrium. Erasin interacts closely with Bip and Calnexin both of which are key players in the ER stress response. By aiding these networks Erasin contributes to cellular health by ensuring that proteins achieve and maintain their correct structures.
Erasin engages in conditions related to protein misfolding and aggregation. Alzheimer's disease and cystic fibrosis are two such disorders where proteostasis is disrupted. In Alzheimer's disease the accumulation of misfolded amyloid-beta peptides links back to Erasin's role in protein folding and clearance. Similarly Erasin's interaction with DeltaF508-CFTR highlights its involvement in cystic fibrosis where proper folding of the CFTR protein is impaired. These associations highlight the pivotal role of Erasin in conditions that challenge cellular protein management.