Abcam, ab242130, Anti-IFFO1 antibody [EPR22711-61]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal IFFO1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22711-61,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFFO1 also known as Intermediate Filament Family Orphan 1 is a protein that plays a role in structural support in cells. It weighs approximately 63 kDa. IFFO1 is expressed in various tissues with a higher concentration in the heart and skeletal muscles and also found in the liver and testis. This target is involved in maintaining the integrity of the cytoskeleton by interacting with other cytoskeletal proteins.
Biological function summary
The protein supports cellular architecture and dynamics during cell division and differentiation. IFFO1 can interact with other intermediate filament proteins but researchers suggest it may also function independently. Though not very well-studied it contributes to the stability of cells' mechanical properties playing a part in maintaining cellular organization and providing resilience against mechanical stress.
Pathways
Its involvement in cytoskeletal organization connects it with the cytoskeletal remodeling pathway which is fundamental for cellular shape and stability. It associates with proteins like vimentin and desmin which are important in this pathway. These interactions underline its contribution to cell structure and mechanics connecting it to both cellular movement and morphological changes.
Evidence links IFFO1 to muscular dystrophy where muscle integrity and function diminish and perhaps to certain liver conditions. The protein interacts with key structural entities like desmin which is also implicated in these disorders. Dysregulation of IFFO1 or its interacting partners may contribute to the disruption of muscle and liver function leading to progressive muscle disorders or hepatic pathologies.