Abcam, ab243247, Anti-SIX1 antibody [1593]

Size: 100µg / 1mg
Mouse Recombinant Monoclonal SIX1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1593,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SIX1 also known as Sine oculis homeobox homolog 1 is a transcription factor with a molecular mass of about 32 kDa. SIX1 plays an important role in regulating gene expression by binding to DNA sequences. This transcription factor shows expression in various tissues including skeletal muscle kidney and neural tissues. In developing tissues the expression is particularly significant indicating its role during embryonic development and differentiation.
Biological function summary
SIX1 influences cell proliferation survival and differentiation. As part of a transcriptional complex it interacts frequently with cofactors like EYA1 to execute its roles in developmental processes. These interactions allow SIX1 to impact gene targets that are important for tissue morphogenesis. The malfunctioning of these processes can lead to developmental disorders highlighting its role in the regulatory networks that govern organogenesis.
Pathways
Several essential biological processes involve SIX1 including the Wnt/β-catenin and TGF-β signaling pathways. In these pathways SIX1 sometimes regulates or interacts with proteins such as β-catenin enhancing transcriptional activation essential for cell fate determination. In the TGF-β pathway SIX1 influences epithelial-mesenchymal transition (EMT) an important event in embryogenesis and metastasis. These pathway involvements indicate its importance in maintaining cellular homeostasis and signaling balance.
SIX1 has a significant link to cancer and congenital anomalies. Overexpression or mutations of SIX1 are often implicated in different cancers such as breast cancer due to its role in facilitating EMT and increasing invasiveness. Moreover SIX1 mutations associate with Branchio-Oto-Renal (BOR) syndrome a developmental disorder that affects the kidneys ears and branchial arches. In these contexts SIX1 connects with other proteins like β-catenin in cancer pathways and EYA1 in BOR syndrome further illustrating its broad impact on health and disease.