Abcam, ab243383, Anti-SLMAP antibody

Size: 100µL
Rabbit Polyclonal SLMAP antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLMAP aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLMAP aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q14BN4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLMAP also known as sarcolemmal membrane-associated protein is a protein of approximately 91 kDa in size. It plays a role in maintaining structure and stability in cells particularly in muscle tissues. The protein localizes primarily to membranes of the sarcolemma a structure associated with muscle cells. Although present in various tissues it shows higher expression within cardiac and skeletal muscles indicating its importance in these areas.
Biological function summary
SLMAP is involved in the organization of the cytoskeletal structure in muscular tissues. It interacts with ion channels and other membrane proteins forming part of a larger complex that stabilizes cellular membranes during muscle contraction and relaxation. SLMAP assists in modulating the activities of these channels impacting cellular excitability and signal transduction. Its role is critical for the integrity of muscle function ensuring proper mechanical and electrical responses in muscle fibers.
Pathways
SLMAP plays a role in the cellular signaling processes important for cardiac muscle homeostasis. It participates in the regulation of ion transport pathways interacting closely with proteins such as ion channel subunits. SLMAP is also associated with muscle contraction pathways where it impacts signaling mechanisms that coordinate muscle function. These interactions highlight its importance in pathways that ensure the efficient functioning of muscle tissues.
Problems with SLMAP expression or function relate to cardiac disorders including cardiomyopathy and arrhythmias. These conditions can stem from disruptions in cardiac ion channel functions a process in which SLMAP plays a critical role. Additionally abnormal SLMAP function may connect to muscular dystrophies where it is part of a network of proteins involving dystrophin that supports muscle integrity. These associations underline SLMAP’s involvement in maintaining muscle health suggesting its potential as a target for therapeutic intervention in relevant diseases.