Abcam, ab243386, Anti-DDX10 antibody

Size: 100µL
Rabbit Polyclonal DDX10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DDX10 aa 400-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DDX10 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.Q13206

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDX10 also known as DEAD box protein 10 functions as an RNA helicase assisting with the unwinding of RNA secondary structures. The protein has a mass of approximately 104 kDa. DDX10 is widely expressed in multiple tissues with higher levels in proliferative tissues. As part of the DEAD box protein family it plays a pivotal role in modulating the dynamics of RNA structures during various cellular processes.
Biological function summary
DDX10 contributes significantly to ribosome biogenesis and RNA processing. It participates in the assembly of ribonucleoprotein complexes ensuring proper assembly and maturation of ribosome subunits. DDX10 often associates with other nucleolar proteins forming complexes that regulate nucleolar activities. Its helicase activity facilitates the processing of ribosomal RNA precursors and affects ribosome production efficiency.
Pathways
DDX10 plays a role in the cell cycle and ribosome biogenesis pathways. It interacts with other proteins involved in ribosomal RNA synthesis including NOP56 and NOP58 raising efficiency rates within ribosome biogenesis pathways. Its involvement in these pathways reinforces its impact on cellular proliferation and growth. Additionally DDX10 integrates with components of the spliceosome highlighting its broader role in RNA metabolism.
DDX10 has associations with myelodysplastic syndromes and acute myeloid leukemia. Alterations in DDX10 expression or function can disrupt ribosome production influencing cell growth and differentiation in hematopoietic cells. In acute myeloid leukemia DDX10 sometimes forms fusion proteins with nucleophosmin (NPM1) which alters the normal molecular activities and contributes to oncogenesis. Understanding these interactions provides insights into potential therapeutic targets for related hematological conditions.