Abcam, ab243815, Anti-MTFMT/FMT antibody

Size: 100µL
Rabbit Polyclonal MTFMT/FMT antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MTFMT aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTFMT aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q96DP5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MTFMT also known as mitochondrial methionyl-tRNA formyltransferase or FMT is an enzyme that plays an important role in protein translation within mitochondria. It adds a formyl group to the initiator methionyl-tRNA which is essential for protein synthesis. MTFMT weighs about 43 kDa and is predominantly expressed in mitochondrial regions of human cells. This enzyme functions in concert with other mitochondrial proteins to ensure efficient initiation of protein translation.
Biological function summary
The enzyme contributes significantly to the process of mitochondrial protein biosynthesis. By formylating methionyl-tRNA MTFMT facilitates the correct start of translation which is critical for mitochondrial function. It does not seem to form part of larger protein complexes but it interacts with other translation machinery proteins to support mitochondrial function effectively. Mitochondria being powerhouses of cells rely on such proteins for the generation of energy in the form of ATP.
Pathways
Methionine formylation by MTFMT integrates into the broader process of mitochondrial translation initiation. This process plays a part in the oxidative phosphorylation pathway a central component of cellular respiration. Within this pathway MTFMT's mechanism is linked to the assembly and function of the electron transport chain. Proteins like MT-ND1 and COX5A which reside in the electron transport chain rely indirectly on MTFMT's action for proper function and assembly of mitochondrial complexes.
Mutations or deficiencies in MTFMT can disrupt mitochondrial protein synthesis leading to mitochondrial diseases. One condition associated with MTFMT malfunction is Leigh syndrome a severe neurological disorder that affects energy production. Such diseases often display overlaps in symptoms linked not just to MTFMT but also to other mitochondrial-related proteins like SURF1 and COX10. These associations underline the critical role of MTFMT in maintaining mitochondrial integrity and cellular energy balance.