Abcam, ab243826, Anti-SLC46A3 antibody

Size: 100µL
Rabbit Polyclonal SLC46A3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC46A3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC46A3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q7Z3Q1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC46A3 also known as Solute Carrier Family 46 Member 3 is a membrane protein facilitating the transport of folate and antifolate compounds across cell membranes. It weighs approximately 53 kDa. Expression of SLC46A3 occurs in several tissues with higher levels in liver and kidney tissues. It plays an essential role in the transport of necessary nutrients and drugs inside the cell.
Biological function summary
SLC46A3 contributes to maintaining cellular homeostasis by regulating folate uptake. While not thought to be part of a larger complex it acts independently to ensure the proper concentration of intracellular folate which is critical for DNA synthesis and repair. Its ability to transport folate emphasizes its importance in maintaining cell proliferation and survival.
Pathways
SLC46A3 influences the folate metabolism pathway and impacts the pharmacokinetics of antifolate drugs such as methotrexate. It works closely with proteins like SLC19A1 another folate transporter to mediate folate and antifolate intracellular concentration. These pathways are essential for understanding drug efficacy and resistance in cancer therapy given folate's role in cell growth.
SLC46A3 alludes to a potential role in cancer and antifolate drug resistance. Its function in drug transport links it to the reduced effectiveness of chemotherapy drugs. Moreover research suggests a connection between SLC46A3 and SLC19A1 both affecting the cellular reaction to antifolate therapies in certain cancer types. Understanding SLC46A3's role could lead to improved therapeutic strategies in oncology.