Abcam, ab244293, Anti-PTPRN2 antibody

Size: 100µL
Rabbit Polyclonal PTPRN2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PTPRN2 aa 350-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PTPRN2 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q92932

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTPRN2 also known as IA-2β or Islet Antigen 2 β is a protein tyrosine phosphatase receptor. It has a mass of approximately 109 kDa. PTPRN2 expresses mainly in neuroendocrine tissues including the pancreas and brain. This protein is involved in vesicular transport and is thought to play a role in the maintenance and function of dense core vesicles. It has a single transmembrane domain and is closely related to other members of the protein tyrosine phosphatase family.
Biological function summary
PTPRN2 participates in the regulation and secretion of hormones and neurotransmitters. It is an integral part of the vesicle trafficking complex impacting the exocytosis process. Studies show that PTPRN2 influences the storage and release of insulin and other neurotransmitters by stabilizing secretory granules. This protein’s expression pattern suggests it may also have roles in neuronal communication and hormone modulation.
Pathways
Research shows PTPRN2 influences the insulin secretory pathway and neuropeptide signaling. It interacts with other proteins like SNAP25 and Synaptotagmin which are involved in synaptic vesicle fusion and neurotransmitter release. PTPRN2’s role in these pathways indicates its importance in communication in neuronal and endocrine systems linking it to broader signaling networks.
PTPRN2 has connections to type 1 diabetes and neurodegenerative diseases. Autoantibodies against PTPRN2 are often detected in patients with type 1 diabetes suggesting its involvement in autoimmune reactions. Additionally abnormal expression or function of PTPRN2 is observed in neurodegenerative conditions like Alzheimer's disease. This highlights its potential role in the progression of these diseases possibly through interaction with neuroprotective proteins or pathways that involve stress responses in neuroendocrine cells.