Abcam, ab244415, Anti-LMOD1 antibody

Size: 100µL
Rabbit Polyclonal LMOD1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LMOD1 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LMOD1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.P29536

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMOD1 also known as Leiomodin 1 is a protein involved in actin filament dynamics. It has a molecular mass of approximately 64 kDa. The protein plays a role in the regulation of actin nucleation and assembly which are critical for the structural integrity and function of muscle cells. LMOD1 is expressed in smooth muscle tissues including those in the vascular system. This expression highlights its functional significance in maintaining smooth muscle contractility.
Biological function summary
LMOD1 contributes to muscle cell contraction by stabilizing and organizing actin filaments. It functions by binding to the pointed ends of actin filaments and may form a part of a multiprotein complex with actin and other actin-binding proteins. This association enhances its capability to regulate actin filament growth and stability factors essential for maintaining cellular structure and motility in smooth muscle tissues. LMOD1's ability to influence actin filament dynamics highlights its significance in muscle cell function and integrity.
Pathways
LMOD1 impacts actin dynamics critical to the smooth muscle contraction pathway. It interacts with proteins such as tropomyosin and tropomodulin influencing actin filament stabilization and organization. The smooth muscle contraction pathway is essential for vascular tone and blood flow regulation. LMOD1's association with actin regulation aligns its role within this pathway impacting smooth muscle cellular contractility and overall smooth muscle function.
LMOD1 is associated with vascular diseases such as arteriosclerosis due to its role in smooth muscle function. Alterations in LMOD1 expression or mutations can lead to abnormal muscle contraction and vascular issues. Additionally LMOD1 has links to hypertensive conditions where dysregulated smooth muscle contraction affects blood pressure control. In these conditions LMOD1 interacts with proteins like actin and tropomyosin which play a role in cellular contractility and are critical in maintaining normal vascular function.