Abcam, ab244455, Anti-LACTB antibody

Size: 100µL
Rabbit Polyclonal LACTB antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LACTB aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LACTB aa 250-350. The exact immunogen used to generate this antibody is proprietary information.P83111

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LACTB protein also known as Serine beta-lactamase-like protein LACTB functions primarily as a serine beta-lactamase-like protein involved in lipid metabolism. It is a mitochondrial protein with a molecular mass of approximately 61 kDa. LACTB is highly expressed in tissues such as the liver and kidney where its role in metabolic and oxidative processes is significant.
Biological function summary
LACTB has a critical function in mitochondrial maintenance and regulation. This protein is a part of the inner mitochondrial membrane and contributes to the regulation of mitochondrial lipid composition and mitochondrial morphology. It does not form a complex but interacts with several mitochondrial proteins to exert its functions. By adjusting the lipid makeup of the mitochondria LACTB influences various metabolic processes and cellular homeostasis.
Pathways
LACTB plays a significant role in oxidative phosphorylation and lipid metabolism pathways. In these pathways it interacts with various proteins that oversee lipid synthesis and mitochondrial function such as cardiolipin and fatty acid synthase. These interactions support energy production and the structural integrity of mitochondria which are essential for proper cellular metabolism and energy homeostasis.
LACTB has connections to cancer and metabolic syndrome. In cancer the protein's regulatory functions on mitochondrial lipid composition impact tumor growth and proliferation. Anomalies in LACTB expression have been associated with altered cellular metabolism observed in some cancers. In metabolic syndrome LACTB influences metabolic pathways altered in this disorder. In these conditions proteins like mTOR (mechanistic target of rapamycin) and AMPK (AMP-activated protein kinase) may interact with LACTB affecting cellular growth and metabolism regulation.