Abcam, ab246861, Anti-CEBPE antibody

Size: 100µL
Rabbit Polyclonal CEBPE antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEBPE aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEBPE aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q15744

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein CEBPE also known as CCAAT/enhancer-binding protein epsilon acts as a transcription factor. It plays a role in overseeing the expression of genes involved in granulocytic differentiation. CEBPE has a molecular mass of approximately 32 kDa. Expression occurs mainly in hematopoietic tissues where it supports the regulation of immune system components and cell cycle processes necessary for the maturation of specific white blood cells like granulocytes.
Biological function summary
CEBPE serves as an important regulator in myeloid cell differentiation and development. It functions within a multiprotein complex that helps influence the transcription regulation of its target genes. This target ensures proper development and differentiation of granulocytes by transcriptionally activating genes important for these processes. This activity highlights its role in maintaining normal immune function and response.
Pathways
CEBPE integrates into several hematopoietic differentiation and signaling pathways. The granulocyte differentiation pathway heavily relies on its transcriptional activity. CEBPE interacts with other critical transcription factors such as PU.1 and GATA-1 to modulate the expression of lineage-specific genes. It helps coordinate the transcriptional cascade that terminates in fully differentiated functionally competent granulocytes.
Mutations or misregulation of CEBPE link to specific types of immune disorders and leukemia particularly acute myeloid leukemia (AML). Altered CEBPE expression interferes with granulocyte maturation leading to pathological conditions. In these diseases the protein cooperates with factors like RUNX1 to disturb normal hematopoietic pathways resulting in unchecked cell proliferation or maturation arrest characteristic of leukemic phenotypes.