Abcam, ab246992, Anti-gamma Adducin antibody

Size: 100µL
Rabbit Polyclonal gamma Adducin antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADD3 aa 550-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ADD3 aa 550-700. The exact immunogen used to generate this antibody is proprietary information.Q9UEY8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gamma Adducin also known as ADD3 is a protein that plays an important role in the assembly of the spectrin-actin cytoskeleton at the cell membrane. It has a molecular mass of approximately 80 kDa. Gamma Adducin is expressed mainly in brain and kidney tissues but can also be found in other organs in smaller amounts. As a member of the adducin family it shares structural similarities with alpha and beta subunits contributing to diverse cellular processes through its interaction capacities.
Biological function summary
Gamma Adducin acts as a regulator of the spectrin-actin network and is involved in the stabilization of membrane structures. It participates in the formation of a larger complex with alpha and beta adducins supporting cellular shape and motility. This protein plays roles in cellular processes such as signal transduction cell adhesion and junction integrity. It is also known to affect cellular activities by modifying membrane-cytoskeleton interactions making it an important player in maintaining cell structure.
Pathways
Gamma Adducin interacts within the Rho signaling pathway and the actin cytoskeleton regulatory pathway. These pathways are essential for cell shape regulation and motility. It works closely with proteins such as actin and spectrin to facilitate cytoskeletal rearrangement and cell signaling networks. Interactions with small GTPases further connect gamma Adducin to pathways that influence changes in cellular architecture.
Gamma Adducin has been linked to hypertension and cardiovascular disease where its function in the membrane skeleton impacts vascular smooth muscle cells' contractility. It interacts with other proteins such as ankyrin and possibly other subunits of adducins in these contexts. Alterations in gamma Adducin expression or mutations can lead to imbalances in cytoskeletal dynamics contributing to disease progression and providing potential therapeutic targets.