Abcam, ab247125, Anti-EPOP/C17orf96 antibody

Size: 100µL
Rabbit Polyclonal EPOP/C17orf96 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EPOP aa 300-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EPOP aa 300-350. The exact immunogen used to generate this antibody is proprietary information.A6NHQ4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPOP also known as C17orf96 is a protein highly relevant in gene expression regulation. It weighs approximately 19 kDa and predominantly expresses in the nucleus. This protein interacts with various other molecules facilitating chromatin remodeling and transcriptional regulation. Regular expression occurs across multiple tissues underlining its versatile nature in different cellular contexts.
Biological function summary
EPOP forms part of the Polycomb Repressive Complex 2 (PRC2) which dynamically modifies histones to regulate gene silencing. EPOP influences the recruitment and retention of PRC2 on chromatin modulating the methylation state of histones. This complex fine-tunes epigenetic landscapes promoting or inhibiting gene expression patterns important for cell differentiation and development.
Pathways
EPOP's activity integrates into epigenetic regulation and development pathways. Its collaboration with PRC2 involves histone methylation essential for the Polycomb group pathway which governs key developmental processes. The interaction with PRC2 highlights the synergistic role EPOP plays with proteins like EZH2 advancing transcriptional regulation critical for sustaining cellular identity.
EPOP dysfunction links to certain cancers and developmental disorders. Aberrations in EPOP's interaction with PRC2 and histone methylation may disrupt normal gene expression leading to oncogenic transformations. Additionally anomalies in EPOP-related pathways could contribute to disorders like schizophrenia where global epigenetic regulation seems affected. Understanding EPOP's influence on histone modification offers insights into such diseases illuminating potential therapeutic avenues to explore.