Abcam, ab247145, Anti-Iroquois homeobox protein 3/IRX3 antibody

Size: 100µL
Rabbit Polyclonal Iroquois homeobox protein 3/IRX3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IRX3 aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IRX3 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.P78415

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Iroquois homeobox protein 3 also known as IRX3 is a transcription factor that plays a role in gene expression regulation. IRX3 weighs approximately 57 kDa. It is expressed in various tissues prominently in the brain heart and skeletal muscle. IRX3 participates in a network of transcription factors that regulates developmental processes and cellular differentiation.
Biological function summary
IRX3 serves an important role in the regulation of embryonic pattern formation. It is a part of the Iroquois homeobox gene family which is involved in the development of distinct anatomical regions during embryogenesis. IRX3 assists in determining body structure and organ formation and forms part of transcriptional complexes that guide the spatial organization of tissues. This protein also interacts with other homeobox proteins to accomplish its roles in development and differentiation.
Pathways
IRX3 integrates into several essential developmental signaling cascades. It is involved in the Wnt signaling pathway influential in cell fate determination embryonic development and homeostasis of adult tissues. In addition IRX3 links with the Hedgehog signaling pathway integral to developmental processes. It functions alongside other proteins such as IRX5 to modulate these pathways’ activities illustrating its role in complex gene interactions and signaling networks.
Studies connect IRX3 to obesity and metabolic syndrome. Variations in the gene locus near IRX3 significantly impact fat distribution and insulin sensitivity. IRX3 may also associate with cardiac disorders as alterations in its expression levels are influenced by its role in heart development. IRX3 interacts with proteins like FTO showing a direct link to metabolic phenotypes and their pathological manifestations.