Abcam, ab247177, Anti-SCHIP1 antibody

Size: 100µL
Rabbit Polyclonal SCHIP1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Schwannomin-interacting protein 1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Schwannomin-interacting protein 1. The exact immunogen used to generate this antibody is proprietary information.P0DPB3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCHIP1 also known as Schwannomin interacting protein 1 is a protein with a mass of approximately 80 kDa. SCHIP1 interacts with the cytoskeleton through binding to neurofibromin 2 (NF2) also called merlin. It is highly expressed in neuronal tissues including the brain and spinal cord. The protein localizes to the cytoplasm and cytoskeletal structures suggesting a role in maintaining cellular structure and integrity.
Biological function summary
SCHIP1 regulates cytoskeletal dynamics and influences cell adhesion and signaling. The protein interacts with actin filament networks contributing to cellular morphology and structural regulation. SCHIP1 forms part of a larger complex involving NF2 and influences actin reorganization. This complex plays an essential role in cellular processes such as motility and division which are critical for the development and function of the nervous system.
Pathways
SCHIP1 significantly impacts the Hippo signaling pathway. This pathway is critical for regulating cell growth proliferation and apoptosis. SCHIP1 interacts with other proteins in the Hippo pathway including YAP and TAZ transcriptional coactivators modulating their activity and subsequent gene expression effects. Moreover through its association with NF2 SCHIP1 influences pathways linked to tumor suppression further highlighting its role in cell cycle regulation.
SCHIP1 is linked to neurofibromatosis type II where mutations in the NF2 gene lead to tumor formation in the nervous system. The interaction between SCHIP1 and NF2 influences pathogenesis by affecting cellular adhesion and proliferation. Additionally abnormalities in pathways involving SCHIP1 may also contribute to cancer progression where uncontrolled cell growth occurs due to disrupted signaling pathways involving YAP and TAZ. Understanding SCHIP1's role in these diseases can provide insights into therapeutic targets for modulating disrupted cellular dynamics and signaling.