Abcam, ab24792, Anti-Claudin 10 antibody

Size: 100µL / 500µL / 1mL
Rabbit Polyclonal Claudin 10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as Claudin 10 also referred to as CLDN10 is a member of the claudin family essential for formation and maintenance of tight junctions. Claudin 10 has a molecular weight of approximately 24 kDa. This protein is expressed widely across various tissues with significant levels in the kidney liver and pancreas. Its main role involves controlling the permeability of epithelial barriers contributing to paracellular transport regulation.
Biological function summary
The function of Claudin 10 includes its involvement in forming and maintaining tight junction strands within epithelial and endothelial cells. It participates in a complex with other claudins to create selectively permeable barriers that regulate ion transport. Claudin 10 plays a role in determining cation selectivity and permeability impacting various physiological processes such as electrolyte balance and fluid homeostasis. In kidney tubules it especially influences the reabsorption and secretion of ions.
Pathways
Claudin 10 interacts with signaling mechanisms that regulate epithelial tight junction integrity. One significant pathway is the Wnt signaling pathway which influences cell polarity and growth affecting tight junction dynamics. Claudin 10 also associates with proteins related to the Par3/Par6/aPKC complex within these pathways. Its function intertwines with those of other tight junction proteins such as ZO-1 and occludin forming a network vital for epithelial cell barrier function and tissue homeostasis.
Altered expression of Claudin 10 has links to kidney disorders such as hypermagnesemia with hypocalciuria due to its important role in magnesium reabsorption. Additionally changes in Claudin 10 function associate with certain liver conditions where disrupted tight junctions may lead to compromised epithelial barrier function. This protein's interaction through disorders often involves connections with the chloride channel protein CLCNKB highlighting its role in ion balance and transport.