Abcam, ab247948, Anti-CEND1 antibody [EPR3739] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CEND1 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3739,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab247948 is the carrier-free version of
ab113076
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEND1 also known as cell cycle exit and neuronal differentiation 1 is a protein with a mass of approximately 16 kDa. Researchers have identified its expression specifically in neural precursor cells of the central nervous system. CEND1 plays a role in controlling neuronal differentiation by interacting with cell cycle regulators. This function highlights its importance in the development of the nervous system and its involvement in maintaining the balance between proliferation and differentiation in neurons.
Biological function summary
CEND1 facilitates neuronal outgrowth and maturation without forming part of a larger multiprotein complex. It acts directly on governing neuronal progenitor cell fate promoting differentiation over proliferation. Researchers have found CEND1 to affect cell cycle arrest in neuronal populations steering progenitor cells towards post-mitotic states essential for healthy neural tissue maturation. The presence of CEND1 in neurogenesis stages establishes it as an important player in the shaping of the neuronal landscape in the brain.
Pathways
Several cell cycle-related pathways involve CEND1 in regulating the transition from proliferation to differentiation in neural progenitors. It interacts with key proteins such as p27^Kip1 and cyclin-dependent kinases. These interactions are important in coordinating neurogenesis and neuronal pathway specification. CEND1 ensures proper function and cooperation with other elements of the neurogenic program including pathways like Notch signaling to regulate the temporal and spatial aspects of neuronal differentiation.
Research has linked CEND1 to neurodevelopmental conditions such as microcephaly and certain forms of epilepsy. Malfunctions or dysregulation of CEND1 can result in impaired neuronal differentiation leading to disturbed neural circuit formation. In these contexts CEND1 interacts with proteins like p53 which governs cell cycle arrest and apoptosis offering insights into how disrupted CEND1 expression contributes to the pathophysiology of these neurological disorders. Understanding these relationships provides potential therapeutic targets for correcting or mitigating such conditions.