Abcam, ab247981, Anti-TAB3 antibody [EPR5965] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TAB3 antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5965,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab247981 is the carrier-free version of
ab124723
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAB3 also known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 is an essential protein that modulates important cellular processes. It has a molecular mass of approximately 90 kDa. The protein functions mechanically to activate downstream signaling pathways acting as an adapter molecule. Expressed ubiquitously TAB3 has more pronounced expression in tissues such as the liver suggesting its potential role in organ-specific functions.
Biological function summary
TAB3 influences multiple cellular signaling mechanisms contributing to the regulation of inflammatory responses and cell survival. It forms a part of important signaling complexes specifically the TAK1 complex which includes TAB1 and TAB2. Together this complex modulates pathways that are important for immune response and stress signaling in cells impacting the cell's ability to respond effectively to external signals.
Pathways
Research shows TAB3's involvement in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. As part of these pathways it interacts closely with other proteins including TAK1 orchestrating a coordinated cellular response to inflammatory and stress stimuli. The activity of these pathways is essential for maintaining proper cell signaling and gene expression under various physiological and pathological conditions.
Studies connect TAB3 to inflammatory and autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Its role alongside TAK1 and NF-κB in these conditions highlights its significance in managing inflammatory responses. Understanding TAB3’s interactions and regulation could offer insights into therapeutic targets for managing these autoimmune and inflammatory diseases.