Abcam, ab248048, Anti-GRO alpha + GRO gamma + GRO beta antibody [EPR4902] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CXCL1/GRO alpha antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4902,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248048 is the carrier-free version of
ab124898
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CXCL1 protein also known as GRO alpha GRO gamma and GRO beta functions as a chemokine involved in the recruitment and activation of neutrophils. The different variants share structural similarities though they have distinct biological effects. It weighs approximately 11 kDa. This target expresses in various tissues with high presence in epithelial cells and endothelial cells as well as in cells of the immune system. Its expression can be highly regulated in response to inflammatory stimuli and it can increase during immune responses.
Biological function summary
This target contributes to inflammation by attracting neutrophils to sites of tissue injury and infection aiding in the immune defense. It does not work as part of a larger complex but it can interact directly with G-protein coupled receptors on leukocytes. These interactions result in the activation of signaling pathways that lead to cell migration and proliferation supporting wound healing and tissue repair processes.
Pathways
CXCL1 is an important player in the chemokine signaling pathway where it interacts with the CXCR2 receptor triggering intracellular signaling cascades. It plays an instrumental role in the NF-kB pathway which regulates the expression of various downstream inflammatory mediators. This chemokine aligns functionally with other CXC chemokines like IL-8 sharing receptor binding to induce similar downstream effects that perpetuate inflammatory responses.
CXCL1 implicates in conditions such as chronic inflammation and cancer. Its overexpression can contribute to pathologies like rheumatoid arthritis where it perpetuates joint inflammation and helps sustain the inflammatory environment. Additionally elevated levels of CXCL1 may also exacerbate tumor progression and metastasis in certain cancers by promoting angiogenesis. In these disease contexts CXCL1 interacts with other inflammatory cytokines like TNF-alpha and IL-1 which together magnify the inflammatory or oncogenic signals.