Abcam, ab24820, Anti-Scn1a antibody

Size: 100µL / 500µL / 1mL
Rabbit Polyclonal SCN1A antibody. Suitable for IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Ab with sodium azide is stable for 24 months when stored at 2-8 °C.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Scn1a gene encodes the Nav1.1 protein a voltage-gated sodium channel alpha subunit. This protein plays an important role in the initiation and propagation of action potentials in neurons. Nav1.1 has an approximate mass of 260 kDa and is primarily expressed in the central nervous system especially in interneurons. These channels are pivotal for maintaining normal neuronal excitability and their regulation underpins nerve impulse transmission.
Biological function summary
Nav1.1 function influences the balance of excitatory and inhibitory signals in the brain. It forms part of the sodium channel complex working alongside beta subunits to modulate gating properties and channel stability. Dysfunction in Nav1.1 affects neuronal excitability leading to altered synaptic transmission which can impact various neural processes and result in neurophysiological abnormalities.
Pathways
Nav1.1 has an integral role in excitatory signal pathways and is key to the propagation of action potentials in neurons. It interacts closely with proteins like Nav1.2 and Nav1.6 which are also sodium channels contributing to electric signal transmission in the nervous system. Nav1.1 participates in neuronal communication pathways which impact processes like synaptic plasticity and overall brain function.
Alterations in Nav1.1 activity are strongly associated with epilepsy specifically Dravet syndrome. Mutations in SCN1A can lead to defective sodium channel function increasing susceptibility to seizures. Nav1.1 is also linked to other proteins like GABA receptors as impaired inhibitory signaling is involved in the pathology of epilepsy. Furthermore potential associations exist with migraine disorders given the protein's influence on neuronal excitability and signal transmission.