Abcam, ab248490, Anti-FGR antibody [EPR3171] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FGR antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR3171,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248490 is the carrier-free version of
ab133349
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FGR protein also known as Src-like adapter protein or FGR proto-oncogene is an important cellular component with a mass of approximately 58 kDa. Expressed mainly in hematopoietic cells like macrophages and neutrophils the FGR protein belongs to the Src family of non-receptor tyrosine kinases. This protein has the ability to modulate various cellular processes through its kinase activity influencing the phosphorylation of substrates involved in signal transduction.
Biological function summary
The FGR protein impacts processes related to immune responses and cell communication. It participates in the formation of multi-protein complexes enabling interactions that mediate pathways important for cellular signaling. Through these interactions the FGR protein controls important processes like cell growth differentiation and movement especially in immune cell types. Its role in signal transduction renders it a critical player in various immune functions.
Pathways
The FGR protein integrates into the signaling networks such as the MAPK/ERK pathway and PI3K/AKT pathway which are pivotal for cell survival and proliferation. Within these pathways FGR interacts with other proteins like the GRB2 and PI3K to mediate downstream effects that influence many cellular responses. These interactions ensure that alterations in external signals lead to appropriate cellular outcomes sustaining a balance in cellular behavior and immune functions.
Alterations in the expression or mutation of the FGR protein have associations with certain cancers and inflammatory diseases. Enhanced FGR activity has been observed in specific leukemia cases where its interaction with proteins like ABL1 and BCR-ABL1 contributes to oncogenic processes. Similarly abnormalities in FGR signaling pathways can result in immune dysfunctions implicating proteins like Lyn and Hck in pathologies such as rheumatoid arthritis. Understanding the role of FGR within disease contexts aids in identifying therapeutic targets for these conditions.