Abcam, ab248628, Anti-FBXO2 antibody [EPR7328(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FBXO2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7328(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248628 is the carrier-free version of
ab133717
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXO2 also known as F-box protein 2 is part of the F-box protein family. This protein plays a mechanical role in recognizing specific substrates for ubiquitination a process important for protein degradation. FBXO2 weighs around 32 kDa and mainly expresses in the brain where it regulates protein levels. This localization suggests its significance in neural protein management.
Biological function summary
FBXO2 participates in forming the SCF (SKP1-CUL1-F-box protein) complex a multi-protein E3 ubiquitin ligase complex. It targets glycosylated proteins for degradation which helps control glycoprotein homeostasis in cells. FBXO2 binds to N-linked glycoproteins indicating its specificity towards glycan recognition and processing. This function makes it important for maintaining cellular protein balance.
Pathways
FBXO2 is involved in the ubiquitin-proteasome pathway which is essential for protein turnover and quality control. It also plays a role in the endoplasmic reticulum-associated degradation (ERAD) pathway which manages misfolded proteins. FBXO2 collaborates with proteins such as β-transducin repeat-containing protein (β-TrCP) within these pathways showing its interaction in various cellular mechanisms.
FBXO2 has connections to neurodegenerative disorders and cancer. Aberrations in FBXO2 function are linked to Alzheimer's disease due to its role in protein degradation in neurons. In cancer FBXO2 alteration affects glycoprotein regulation potentially leading to tumor progression and metastasis. The protein relates to other F-box proteins which also influence cellular stability and disease progression.