Abcam, ab248919, Anti-HOXA5 antibody [EPR2825(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal HOXA5 antibody. Carrier free. Suitable for WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2825(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248919 is the carrier-free version of
ab140636
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HOXA5 protein is a transcription factor known for its role in regulating gene expression. Alternate names include Homeobox A5 and it belongs to the cluster of homeobox genes. HOXA5 has a molecular mass of approximately 30 kDa. This protein is expressed in various tissues including the lungs kidneys and the developing spinal cord. Its expression shows spatial and temporal specificity during embryonic development.
Biological function summary
It functions as a part of the larger HOX family which comprises transcription factors that orchestrate body plan and segmentation. HOXA5 impacts cell differentiation and organogenesis. It modulates signaling pathways affecting processes like apoptosis and angiogenesis by activating or repressing genes depending on its expression level and cellular context.
Pathways
It plays a critical role in the Wnt pathway by interacting with secreted proteins that regulate the pathway. Additionally it intersects with the TGF-beta signaling cascade contributing to tissue morphogenesis. These pathways dictate the function and interaction of HOXA5 with proteins like beta-catenin and SMADs. Such interactions ultimately influence cell fate decisions and tissue remodeling.
Its deregulation has been implicated in the pathogenesis of lung cancer through its effects on cell proliferation and apoptosis. In congenital diaphragmatic hernia HOXA5's role in normal diaphragm development becomes evident when its function is compromised. The dysregulated expression of HOXA5 often shows linkage with proteins such as p53 highlighting a shared pathway contributing to oncogenic events.