Abcam, ab248983, Anti-HERPUD1 antibody [EPR9649] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal HERPUD1 antibody. Carrier free. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9649,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248983 is the carrier-free version of
ab150424
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HERPUD1 also known as Herp is a protein involved in the cellular response to stress especially related to the endoplasmic reticulum (ER). It has a molecular mass of approximately 42 kDa. This protein is expressed in various tissues with high expression levels found in the liver heart and muscle. HERPUD1 becomes particularly upregulated during conditions that cause ER stress helping cells manage misfolded proteins.
Biological function summary
HERPUD1 helps maintain cellular homeostasis during periods of ER stress by facilitating the degradation of misfolded proteins. It forms part of a larger complex in the ER-associated degradation (ERAD) pathway which targets these proteins for retrotranslocation and subsequent destruction by the proteasome. HERPUD1 therefore plays a vital role in mitigating the buildup of potentially harmful proteins within the cell.
Pathways
HERPUD1 is integral to the unfolded protein response (UPR) and the ERAD pathway. In the UPR HERPUD1 is involved in signaling mechanisms that help restore normal ER function. It interacts with other proteins such as SEL1L and DERLIN-1 within the ERAD pathway to ensure the proper disposal of misfolded proteins preventing cellular damage.
HERPUD1 is connected with neurodegenerative diseases and cardiac disorders. Its dysfunction or dysregulation can lead to the accumulation of misfolded proteins contributing to conditions like Alzheimer's disease. Moreover HERPUD1's relationship with proteins such as ubiquitin suggests its involvement in cardiac stress responses which can be significant in heart failure. HERPUD1's functions and interactions underline its importance in cellular stress responses and associated disease states.