Abcam, ab248987, Anti-SH3GL1 + SH3GL2 + SH3GL3 antibody [EPR10215(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SH3GL2 antibody. Carrier free. Suitable for WB and reacts with Recombinant fragment - Human, Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10215(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248987 is the carrier-free version of
ab150431
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH3GL2 also known as Endophilin A1 is a protein that plays an important role in membrane dynamics during endocytosis. It has a molecular weight of approximately 41 kDa. Mechanically SH3GL2 binds to lipids and helps in membrane curvature due to its BAR domain. This protein is highly expressed in neuronal tissues where it participates in synaptic vesicle endocytosis. It interacts with other proteins via its SH3 domain facilitating the assembly of protein complexes involved in these cellular processes.
Biological function summary
SH3GL2 is involved in synaptic vesicle recycling an important process for neurocommunication. It is part of a complex that includes proteins such as dynamin and synaptojanin. It ensures the rapid turnover of synaptic vesicles by mediating their endocytosis and recycling back to the synaptic terminal. This function helps in maintaining efficient synaptic transmission essential for neuronal communication and plasticity.
Pathways
SH3GL2 is involved in the clathrin-mediated endocytosis pathway. This pathway is critical for the retrieval of synaptic vesicles in neurons. SH3GL2 works closely with clathrin and dynamin to facilitate the budding and scission of vesicles from the plasma membrane. In addition SH3GL2 also interacts within the synaptic vesicle cycle ensuring the availability of vesicles for neurotransmitter release.
SH3GL2 has been linked to neurodegenerative diseases such as Parkinson's disease. Its interaction with proteins like alpha-synuclein suggests its role in the pathogenesis of this disorder. Altered SH3GL2 function may disrupt normal synaptic vesicle dynamics contributing to neuronal dysfunction. Furthermore aberrant SH3GL2 expression or function may also be involved in schizoaffective disorders where its interaction with synaptojanin plays a role in synaptic dysfunction.