Abcam, ab248997, Anti-TOX3 antibody [EPR6173(2)(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal TOX3 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6173(2)(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab248997 is the carrier-free version of
ab151548
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TOX3 also known as TOX high mobility group box family member 3 is a transcription factor with a significant role in chromatin remodeling and gene expression regulation. It has a molecular mass of approximately 60 kDa. TOX3 mainly gets expressed in neuronal tissues but it is also found in breast tissue and embryonic development sites. As a transcription factor TOX3 influences cellular processes by binding to DNA and interacting with other proteins to control the transcription of target genes. Through these interactions TOX3 can activate or suppress specific genes in different contexts.
Biological function summary
TOX3 interacts with other components to influence neural development and neuroplasticity. It does not strictly operate as a lone factor; rather it associates with protein complexes for its functions. This protein plays an important part in the survival and function of neurons. In breast tissue TOX3 may influence cellular architecture and receptor signaling pathways that are important for tissue differentiation and maintenance. The dynamic role of TOX3 in various tissues marks it as a versatile regulator essential for a broad range of cellular processes.
Pathways
TOX3 integrates into the Wnt signaling and estrogen receptor pathways. These pathways are critical for developmental processes and cell fate determination. Within the Wnt signaling pathway TOX3 interacts with downstream effectors to modulate the transcriptional outcomes. In relation to the estrogen receptor pathway TOX3 links with other transcription factors such as FOXA1 to regulate target genes in hormone-responsive tissues. These interactions place TOX3 as a significant intermediary in conveying signals from external cues to drive specific cellular outcomes.
TOX3 links closely to breast cancer and neurodegenerative diseases like Alzheimer's disease. In breast cancer alterations in TOX3 expression levels correlate with disease progression and prognosis often in connection with altered functions of estrogen receptors and BRCA1. In neurodegenerative contexts TOX3 participates in pathways affecting neuronal survival and may share mechanistic links with proteins like APP linked to Alzheimer's disease pathology. The dual involvement in cancer and neurological diseases highlights TOX3 as a potential target for therapeutic intervention.