Abcam, ab249062, Anti-MGT4A antibody [EPR10034] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MGT4A antibody. Carrier free. Suitable for IHC-P, ICC/IF, WB, IP, Flow Cyt and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10034,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IP, Flow Cyt, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249062 is the carrier-free version of
ab151750
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MGT4A also known as Magnesium Transporter 4A is a protein involved in magnesium ion translocation. Weighing approximately 40 kDa this protein functions as an integral membrane protein primarily facilitating the movement of magnesium ions across cellular membranes. MGT4A can be found expressed in various tissues with significant levels observed in the intestinal epithelium. It plays a critical role in maintaining magnesium homeostasis within cells.
Biological function summary
The magnesium transporter MGT4A helps regulate intracellular magnesium levels which are important for numerous cellular functions including enzymatic reactions and signal transduction. MGT4A operates as part of a larger magnesium transport complex that is responsible for ensuring the proper uptake and distribution of magnesium ions within cells. This regulation is essential for maintaining the activity of many magnesium-dependent processes within the body.
Pathways
Magnesium homeostasis is an important function of MGT4A and it participates in cellular metabolism and energy production pathways. MGT4A interacts with proteins involved in the cation transport pathway ensuring balanced magnesium levels which are necessary for ATP production and DNA synthesis. It is also related to the transporter family that includes other cation transport proteins which have roles in similar biological pathways.
Mutations or malfunctions in MGT4A can lead to conditions such as hypomagnesemia and hypertension. These diseases stem from disrupted magnesium levels affecting cardiovascular and epithelial cell functions. In the context of these conditions MGT4A interacts with other transporter proteins like those involved in calcium and sodium ion transport underlining its significance in ion homeostasis and highlighting its potential as a therapeutic target for related disorders.