Abcam, ab249256, Anti-Syntaxin 18 antibody [EPR8939] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Syntaxin 18 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Mouse, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8939,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249256 is the carrier-free version of
ab156017
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Syntaxin 18 also known as STX18 is a membrane protein that plays an important role in intracellular protein transport. This protein has an approximate molecular mass of 34.5 kDa and primarily resides in the endoplasmic reticulum (ER). Syntaxin 18 helps mediate vesicle trafficking facilitating the movement of different molecules between the ER and the Golgi apparatus. It acts as a target-specific SNARE protein which stands for "soluble N-ethylmaleimide-sensitive factor attachment protein receptor." SNARE proteins are known for their role in fusion processes of transport vesicles to their target membranes.
Biological function summary
Syntaxin 18 is involved in maintaining cellular homeostasis. It functions as part of a larger complex often referred to as the Syntaxin 18 complex which also includes other proteins such as SNARE partners Use1 BNIP1 and Sec22b. This protein complex is essential in the post-translational transport of proteins from the ER to the Golgi. Syntaxin 18 ensures precise vesicle targeting and fusion which is important for proper cell function and protein maturation processes within the secretory pathway.
Pathways
Syntaxin 18 integrates into the secretory pathway where it coordinates with other proteins like VAMP7 and SNAP29 to facilitate vesicle transport. This pathway is vital for the regulation of protein and lipid shipping within cells. Syntaxin 18 also plays an integral role in the ER-to-Golgi transport vesicles which are important in protein secretion and autophagy. As Syntaxin 18 is linked to proteins involved in vesicular trafficking it is critical in ensuring that cellular components are distributed efficiently within the cell.
Syntaxin 18 has associations with neurodegenerative disorders such as Alzheimer's disease due to its role in protein traffic dysregulation. Abnormal expression or mutations in Syntaxin 18 can disrupt vesicular transport leading to cellular stress and pathological aggregates that relate to these diseases. Furthermore Syntaxin 18 interacts with proteins like VAMP7 which also impacts processes implicated in certain autoimmune diseases. Understanding these interactions provides insights into how impaired Syntaxin 18 function contributes to disease progression.