Abcam, ab249359, Anti-ERH antibody [EPR10830(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ERH antibody. Carrier free. Suitable for IHC-P, ICC/IF, IP, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10830(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249359 is the carrier-free version of
ab166620
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ERH short for Enhancer of Rudimentary Homolog is a small protein involved in transcriptional processes. Also known in scientific literature by its alias 'e 'r 'h ' it has a molecular weight of approximately 12 kDa. ERH is widely expressed in various tissues indicating its broad role in cellular function. The protein contains two conserved domains that contribute to its ability to interact with other proteins in cellular processes.
Biological function summary
ERH participates in transcription and RNA processing functions through its involvement with RNA binding. ERH forms part of a multi-protein complex that includes other components such as mRNA splicing factors. Its role is essential in ensuring the proper processing of precursor mRNA molecules into mature mRNAs. Such molecular functions highlight ERH's importance in maintaining the efficiency of transcription and post-transcriptional modifications.
Pathways
Researchers have observed ERH's participation in gene expression and cell cycle pathways. Within these pathways ERH interacts with proteins like DIDO1 and SMARCA4 which are linked to chromatin remodeling and mRNA splicing respectively. The coordination of these proteins with ERH amplifies its significance in regulating gene expression and ensuring proper cell cycle progression.
ERH has connections to cancer and neurodevelopmental disorders. Alterations in ERH expression levels are associated with malignancies where its interaction with proteins such as LSF1 and SETDB1 can contribute to tumorigenesis. Similarly the disruption of ERH function links to neurodevelopmental disorders potentially through aberrant mRNA processing and gene expression regulation. These associations underline ERH as an important target for studying therapeutic interventions in these diseases.