Abcam, ab249462, Anti-HOXC13 antibody [EPR5626] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal HOXC13 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5626,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249462 is the carrier-free version of
ab168368
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXC13 also known as Homeobox protein Hox-C13 is a transcription factor belonging to the homeobox gene family. This protein plays a significant role in regulating gene expression influencing cellular proliferation and differentiation. HOXC13 has a mass of approximately 37 kDa and is expressed in specific tissues including hair follicles the skin and certain regions of the central nervous system. The protein contains a homeodomain which allows it to bind DNA and control the transcription of genes essential for proper development.
Biological function summary
HOXC13 influences the development and maintenance of hair and skin by regulating the expression of keratin genes. As a member of the homeobox gene complex it contributes to the establishment of body plans during embryonic development. HOXC13 acts not alone but as part of transcriptional complexes that modify expression patterns of target genes ensuring proper structural attributes of tissues. Its activity impacts cellular differentiation impacting phenotypic characteristics such as hair texture and skin structure.
Pathways
HOXC13 plays a role in the Wnt signaling pathway and epidermal differentiation processes. It interacts with other HOX proteins such as HOXC8 and HOXD13 contributing to the regulation of gene networks involved in skin and appendage formation. These pathways dictate cellular fate ensuring coordinated development and function of keratinocytes in the epidermis as well as hair follicle morphogenesis and cycling.
Alterations in HOXC13 expression or function have been associated with ectodermal dysplasia and hair abnormalities. Mutations or dysregulation of this protein disrupt normal hair and skin development often leading to phenotypes of clinical importance like hypotrichosis. HOXC13 has been implicated in ectodermal dysplasias through its regulatory relationships with genes responsible for keratin synthesis highlighting its importance in integumentary system anomalies.