Abcam, ab249495, Anti-CR1L antibody [EPR9604(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Crry antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9604(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249495 is the carrier-free version of
ab169543
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CR1L also known as CR1-like or C3b/C4b receptor 1-like is a protein encoded by the CR1L gene. This protein functions mechanically as a receptor that interacts specifically with complement components C3b and C4b playing roles in immune complex processing. The molecular mass of CR1L is approximately 130 kDa. Expression of CR1L occurs mostly in the liver certain cells of the hematopoietic lineage and in platelets.
Biological function summary
CR1L acts as part of the immune system by binding to complement fragments on opsonized pathogens which facilitates their clearance. It forms part of a receptor complex that clears immune complexes and helps in modulating the complement cascade. CR1L's involvement in complement regulation highlights its contribution to preventing excessive inflammation and protecting host tissues during immune defense.
Pathways
CR1L plays a significant role in the complement activation pathway specifically in classical and alternative pathways. These pathways involve proteins such as factor H and factor I which work alongside CR1L to ensure proper regulation of complement activity. By binding C3b and C4b CR1L helps in the breakdown of these components and assists in maintaining homeostasis by moderating complement activity.
CR1L associates with autoimmune conditions such as systemic lupus erythematosus and atypical hemolytic uremic syndrome. These disorders often involve dysregulation of complement activity. CR1L interacts with other complement regulatory proteins such as complement receptor 2 (CR2) in these contexts where imbalances in complement system function can lead to tissue damage and inflammation.