Abcam, ab249518, Anti-LINGO3 antibody [EPR9635] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal LINGO3 antibody. Carrier free. Suitable for ICC/IF, IP, WB, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9635,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249518 is the carrier-free version of
ab169772
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein LINGO3 also known as Leucine-Rich Repeat and Ig Domain-Containing contributes to regulating neuronal survival and function. LINGO3 has a molecular mass of approximately 87 kDa and shows expression mostly in the central nervous system. It belongs to the LINGO family which includes several proteins that share overlapping functions in the nervous system.
Biological function summary
LINGO3 plays a significant role in the development and maintenance of neuronal circuits. It often partakes in protein complexes that influence nerve growth and guidance. Its action affects cellular functions such as differentiation and axonal growth contributing to the proper configuration of neural networks.
Pathways
LINGO3 engages with mechanisms involved in neuronal signal transduction and myelination. It operates within the axon guidance pathway and the Nogo receptor pathway. In these pathways proteins such as RTN4 (also known as Nogo) interact with LINGO3 to modulate neuronal growth and inhibition of neurite outgrowth.
LINGO3's activity could connect with multiple sclerosis and neurodegenerative conditions. The dysregulation of LINGO3 affects axonal integrity and remyelination processes which are important in the progression of these disorders. LINGO3 relates to proteins like Nogo and MAG which are pivotal in neuropathological conditions impacting myelin stability and repair.