Abcam, ab249606, Anti-WDR16 antibody [EPR11263] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal WDR16 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11263,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249606 is the carrier-free version of
ab170937
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR16 also known as WD repeat domain 16 is a protein that is involved in several cellular processes through its structural role. It has a molecular mass of approximately 47 kDa and displays expression in various human tissues including the lungs brain and kidney. The protein belongs to the WD repeat protein family characterized by distinct WD repeat structures that facilitate protein-protein interactions.
Biological function summary
WDR16 contributes to important cellular functions and it often participates as part of multiprotein complexes. The protein shows involvement in the regulation of ciliary functions aiding in the proper formation and maintenance of cilia. This role makes it significant in supporting cells' roles in movement fluid flow and sensory functions. Through this biological involvement WDR16 helps ensure proper communication and signaling within cells that contain cilia.
Pathways
WDR16 plays a part in ciliary assembly and maintenance critical for the ciliogenesis pathway. This pathway involves several other proteins such as IFT20 which helps in the transport of ciliary components. Additionally WDR16 has interactions in the Wnt signaling pathway although its specific mechanisms are less thoroughly explored compared to its role in ciliary processes. These pathways emphasize WDR16's role in maintaining cellular structure and signaling required for normal cell function.
Mutations or dysfunction of WDR16 link to ciliopathies a group of disorders caused by defects in cilia structure and function. One such disease is nephronophthisis a kidney disorder characterized by inflammation and fibrosis. In this context WDR16 can connect with proteins like NEK8 which are implicated in similar pathways and disorders. Understanding these connections helps provide insight into the roles of WDR16 in disease pathology and potential therapeutic targets.