Abcam, ab249649, Anti-FRMD6/Willin antibody [EPR12261] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal FRMD6/Willin antibody. Carrier free. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12261,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249649 is the carrier-free version of
ab171745
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRMD6 also known as Willin is a protein that functions by acting as a scaffold within cells influencing cell shape and motility. This protein has an approximate mass of 78 kDa. FRMD6 is expressed in multiple tissues including the brain with noticeable presence in neuronal cells. It plays a role in the organization of actin cytoskeleton impacting cell adhesion and polarity.
Biological function summary
FRMD6 influences signaling pathways that regulate growth and differentiation. It contributes as part of a regulatory complex that communicates signals from the extracellular matrix to intracellular pathways. The protein is not known to be part of a stable complex but it interacts dynamically with several cytoskeletal elements during cell signaling events. It assists in transducing signals necessary for maintaining cellular architecture and function.
Pathways
FRMD6 is significantly involved in the Hippo signaling pathway which regulates cell proliferation and apoptosis. This pathway controls tissue growth and cancer development through interaction with proteins like YAP and TAZ. FRMD6 operates upstream within this pathway contributing to the suppression of cell growth by modulating these transcriptional coactivators.
FRMD6 associates with diverse pathological conditions. In cancer aberrant expression or function of FRMD6 interrupts normal Hippo pathway signaling potentially promoting tumorigenesis. Additionally studies have linked FRMD6 with neurological disorders reflecting its expression in neuronal tissues. It connects with proteins like LATS1 and MOB1A in these disorders influencing their roles within the affected pathways.