Abcam, ab249691, Anti-NUDCD2 antibody [EPR11558] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal NUDCD2 antibody. Carrier free. Suitable for IHC-P, ICC/IF, IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11558,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249691 is the carrier-free version of
ab171979
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NUDCD2 also known as NudC Domain Containing 2 is a protein that plays a role in cellular processes like protein transport. This protein weighs approximately 45 kDa. NUDCD2 locates primarily in the cytoplasm where it interacts with microtubules. The expression profile of NUDCD2 shows its presence in multiple tissues including liver lungs and lymph nodes highlighting its significance in these areas.
Biological function summary
The actions of NUDCD2 involve interactions with the mitotic spindle suggesting a role in cell division. NUDCD2 associates with elements of the dynein-dynactin complex which implies participation in intracellular transport mechanisms. This complex facilitates processes essential for efficient mitotic spindle function an important aspect of cell division and proper chromosome segregation.
Pathways
NUDCD2 is involved in the regulation of the microtubule cytoskeleton. It functions within pathways like the cell cycle regulation pathway in particular during mitosis. NUDCD2 is related to proteins such as dynein which contribute to the stabilization of microtubules and proper mitotic spindle formation. This connection indicates that NUDCD2 impacts processes that control cell proliferation and genomic stability.
NUDCD2 has connections to cancer where disruptions in its function could lead to abnormal cell division and tumor formation. Impaired regulation of proteins like NUDCD2 might result in missegregation of chromosomes promoting oncogenesis. Additionally NUDCD2 implications in neurological disorders exist since defects in microtubule-related processes can lead to neurodevelopmental issues linking it with proteins involved in neuronal function and stability.