Abcam, ab249737, Anti-IGF1 Receptor+Insulin Receptor antibody [EPR2334(2)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal IGF1 Receptor antibody. Carrier free. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2334(2),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249737 is the carrier-free version of
ab172965
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The IGF1 Receptor also known as CD221 and Insulin Receptor are tyrosine kinase receptors with a mass of approximately 155 kDa each. These receptors are mainly expressed on the surface of cells in tissues like muscle liver and adipose tissue. They share structural homology and can form hybrids of the type IGF1R/Insulin Receptor. Both receptors promote cellular signaling by binding their respective ligands Insulin-like Growth Factor 1 (IGF1) and Insulin leading to autophosphorylation and activation of intracellular signaling cascades.
Biological function summary
These receptors play essential roles in processes including growth metabolism and development. They are part of larger signaling complexes involving several adaptor and signaling proteins. These receptors regulate the uptake of glucose into cells promote cell growth and inhibit apoptosis. Their activity impacts processes such as protein synthesis cell proliferation and differentiation linking energy availability to cellular functions.
Pathways
The IGF1 Receptor and Insulin Receptor participate in the PI3K/AKT and MAPK/ERK pathways. These pathways are essential for regulating cellular growth survival and metabolism. Proteins such as IRS-1 and Shc participate in these signaling pathways. In these processes PI3K/AKT signaling is particularly influential in controlling glucose metabolism and cellular growth while MAPK/ERK modulates cell proliferation and differentiation.
Abnormalities in IGF1 Receptor and Insulin Receptor signaling are linked to disorders such as cancer and diabetes. These receptors are associated with cancer by participating in tumorigenic processes like enhanced cell proliferation and survival. Regarding diabetes defects in Insulin Receptor signaling can result in insulin resistance a critical component of type 2 diabetes. In both conditions proteins such as IRS-1 and PI3K further influence disease progression by mediating downstream effects of impaired receptor function.