Abcam, ab249861, Anti-MRPS17 antibody [EPR12583] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MRPS17 antibody. Carrier free. Suitable for IHC-P, ICC/IF, IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12583,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, IHC-P, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249861 is the carrier-free version of
ab175207
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPS17 also known as mitochondrial ribosomal protein S17 is a component of the mitochondrial ribosome small subunit. It weighs approximately 17 kDa. MRPS17 expresses in tissues throughout the body especially in those with high-energy requirements like muscle and brain. MRPS17 is essential for mitochondrial protein synthesis where it contributes to translating mitochondrial-encoded messages into functional proteins.
Biological function summary
The protein MRPS17 acts as part of the mitochondrial ribosome which contains many different proteins and ribosomal RNA. This complex plays a significant role in cellular energy metabolism by producing proteins essential for the electron transport chain. MRPS17 ensures that mitochondria maintain their capacity to synthesize proteins that drive ATP production. Without this process cells would lack adequate energy supply.
Pathways
MRPS17 engages in critical roles within mitochondrial translation pathway and oxidative phosphorylation pathway. These pathways facilitate the proper function of mitochondria in energy production. MRPS17 interacts with other mitochondrial ribosomal proteins like MRPS18 ensuring the accuracy and efficiency of protein synthesis. This interaction supports overall mitochondrial and cellular health.
Defects in MRPS17 relate to mitochondrial diseases such as Leigh syndrome and mitochondrial cardiomyopathy. These conditions often arise from disrupted energy production in cells. Genetic mutations affecting MRPS17 might impair mitochondrial function leading to clinical symptoms. MRPS17 shares connections with other mitochondrial proteins like MRPS16 in the context of these disorders highlighting its relevance in related pathological states.