Abcam, ab249978, Anti-BTNL3 antibody [EPR8411(2)(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal BTNL3 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8411(2)(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab249978 is the carrier-free version of
ab177473
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTNL3 also known as butyrophilin-like 3 is a protein that plays a role in immune system regulation. It has a molecular weight of approximately 55 kDa and is primarily expressed in the epithelial tissues including the skin and gut. BTNL3 belongs to the butyrophilin family which is part of the immunoglobulin superfamily. This protein is recognized for its function in modulating immune responses by interacting with T cells through its extracellular domains.
Biological function summary
BTNL3 influences immune cell activity by acting as a modulator affecting the activation and suppression of T cells. BTNL3 can form a complex with other butyrophilin-like proteins such as BTNL8 to exert its regulatory effects. Its expression in epithelial tissues suggests a role in maintaining epithelial barrier integrity and immune homeostasis at these sites.
Pathways
BTNL3 takes part in the regulation of T cell receptor signaling. It contributes to the broader immunological pathways including the adaptive immune response. Other proteins like BTN3A1 interact within these pathways to modulate immune cell function and ensure balanced immune responses highlighting the coordinated actions required for proper immune surveillance.
BTNL3 has connections to inflammatory bowel disease and skin disorders. Altered expression or function of BTNL3 may disrupt the immune equilibrium contributing to these conditions. Furthermore it intersects with proteins such as BTNL8 which may also be implicated in these pathological states indicating the importance of BTNL3 in maintaining immune health and its potential as a therapeutic target.